Microorganisms in the area of high permeability reservoir growth, reproduction and production of polymers, so that it can be selectively blocked large pore, increasing the sweep coefficient and reduce water-oil ratio. Increasing water in the water flooding in Pellet mill machine, reduce the mobility of the water phase, reducing the fingering and premature flooding, improve sweep efficiency, increasing sweep efficiency. Resulting in the formation of biopolymers, in a high permeability zone control flow ratio, adjust the water reservoir water profile, increasing the sweep area, increase recovery. Microbial water flooding into the reservoir, the growth and reproduction of bacteria and metabolic products with machine for pellets to form a precipitate, having a high water blocking effect, blocking rate can reach 99% (pure cell plugging effect can only be up to 25%). This heterogeneous reservoir of water shutoff economy better, can increase oil production and recovery, as sealing off the hypertonic Transparent strips, also helps to reduce water injection.